髓寡细胞糖蛋白抗体相关的大脑皮层脑炎,具有超耐火状态的
Yayoi Shide-Moriguchi1, Naohiro Yamamoto2, Ichiro Kuki3
1Department of Pediatrics, Nara Prefecture General Medical Center, Nara, Japan.
Brain & development
|September 11, 2024
概括
在髓寡细胞糖蛋白抗体相关的大脑皮层脑炎 (MOG-CCE) 中发作的管理可能是具有挑战性的. 这一案例突显了MOG-CCE中对超耐火性状态的内甲和连续胺输液的疗效.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 髓寡细胞糖蛋白抗体相关的大脑皮层脑炎 (MOG-CCE) 经常伴有发作.
- 对MOG-CCE有效的急性发作管理策略仍未确定.
研究的目的:
- 报告一种具有超耐火状态 (SRSE) 的MOG-CCE病例.
- 评估MOG-CCE中耐火性发作的新型治疗干预措施的有效性.
主要方法:
- 一名患有MOG-CCE的9岁男孩出现了长时间的发作和SRSE耐硫.
- 治疗包括持续的胺注射和内甲松治疗 (IT-DEX).
- 该患者还接受了甲基普雷迪尼索隆脉冲治疗和口服普雷迪尼索隆.
主要成果:
- 持续的胺注射和IT-DEX迅速阻止了发作.
- 患者在6个月的随访期内没有出现复发.
- 通过脑脊液和血清中阳性抗转基因抗体证实了诊断.
结论:
- 在MOG-CCE中可以出现超耐药性状态,并且可能对标准抗发作药物耐药.
- 在MOG-CCE中,内甲和连续胺输液是控制发作的可行的治疗选择.
- 这种方法可能类似于用于发烧性感染相关综合征的治疗方法.
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