对于瓦尔酸诱导的毒性而言,L-卡尼丁.
Tomasz Gziut1, Ruben Thanacoody1,2
1National Poisons Information Service (Newcastle unit), Newcastle-upon-Tyne Hospitals NHS Foundation Trust, UK.
British journal of clinical pharmacology
|September 11, 2024
概括
卡尼丁可以治疗酸毒性,包括肝损伤和高氨水平. 建议采用静脉注射的加重剂量,然后进行连续输液,而不是口服或胆囊方法,以获得更好的结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
- 临床毒理学 临床毒理学
背景情况:
- 酸 (VPA) 广泛用于和双相情感障碍.
- VPA代谢可能导致肝毒性和高血.
- 对于线粒体脂肪酸代谢来说,L-卡尼丁是至关重要的.
研究的目的:
- 审查L-卡尼丁对VPA诱导毒性的有效性.
- 为了确定VPA毒性中L-卡尼丁的最佳剂量和施用途径.
主要方法:
- 关于L-卡尼丁的药理动力学和临床应用的文献综述.
- 对VPA诱导的不良影响研究的分析.
主要成果:
- VPA毒性包括肝毒性和高氨血症.
- 根据服用途径 (口服14-18%),L-卡尼丁的生物可用性有所不同.
- 脏清除L-卡尼是剂量依赖的.
结论:
- 证据支持L-carnitine用于VPA诱导的高氨血和肝毒性.
- 最佳的L-卡尼丁剂量和途径尚不清楚.
- 倡导静脉注射充满剂量 (5 mg/kg),然后进行连续输液.
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