轴性脊柱关节炎中的糖尿病:观察性研究的系统审查和元分析
Leher Gumber1,2, Harini Samarasinghe3, Praveen Gladston4
1Translational and Clinical Research Institute, Newcastle University, Newcastle-upon- Tyne, UK.
Rheumatology international
|September 11, 2024
概括
轴性脊柱关节炎 (axSpA) 患者患糖尿病的患病率更高. 这一系统性审查发现,axSpA患者的糖尿病患病率为7.0%,这表明风险增加和需要进行常规查.
科学领域:
- 风湿病学和内分泌学.
- 心血管疾病研究研究
背景情况:
- 轴性脊椎关节炎 (axSpA) 是一种慢性炎症性疾病,与心血管疾病 (CVD) 风险增加有关.
- 糖尿病是一种重要的,已确定的心血管疾病和中风风险因素.
研究的目的:
- 系统地审查和确定 axSpA.患者糖尿病的患病率.
- 为了比较患有axSpA的患者与没有这种疾病的患者患糖尿病的风险.
主要方法:
- 从2000年1月到2023年11月,在Medline,Embase和Scopus进行了全面的文献搜索.
- 包括观察性研究报告axSpA患者糖尿病患病率,发病率或风险.
- 随机效应元分析被用来结合研究特定的比例和几率比率 (OR).
主要成果:
- 对23项涉及65,025名患者的研究的分析显示,axSpA个体的综合糖尿病患病率为7.0% (95% CI 5.9-8.0%).
- 与对照组相比,1.29 (95% CI 1.10-1.52) 的合并OR表明axSpA患者患糖尿病的风险增加.
- 对称的漏斗图表表明没有显著的小研究效应,支持研究结果的稳定性.
结论:
- 这些发现表明,轴性脊柱关节炎患者的患病率更高,糖尿病风险可能更高.
- 建议 axSpA 患者队列进行糖尿病常规查,并促进生活方式的改变.
相关概念视频
Autoimmune Disorders
396
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
396
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
Diabetes: Symptoms, Diagnosis, and Complications
520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520


