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相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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相关实验视频

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Transcriptome Analysis of Single Cells
07:27

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细胞子集中的单细胞转录组特征与单细胞转录组特征相反的衰老效应.

Daigo Okada1

  • 1Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, 53 Syogoin-Kawaramachi, Sakyo-ku, Kyoto, 606-8507, Japan. dokada@genome.med.kyoto-u.ac.jp.

Biogerontology
|September 11, 2024
PubMed
概括

衰老对细胞类型的基因表达有不同的影响,有些细胞表现出增加的活性,而另一些细胞表现出减少的活性. 这种相反的衰老效应很普遍,特别是在参与核糖体功能和翻译的基因中.

科学领域:

  • 基因组学就是基因组学.
  • 衰老研究研究 衰老研究
  • 细胞生物学 细胞生物学

背景情况:

  • 基因表达随着年龄的增长而发生变化,因性别,组织和细胞类型而异.
  • 了解这些与年龄相关的基因表达模式对于衰老研究至关重要.

研究的目的:

  • 为了研究在不同细胞子集中对基因表达的广泛"相反的衰老效应".
  • 分析衰老如何影响各种细胞类型内的转录组多样性.

主要方法:

  • 利用了Tabula Muris Senis数据集,这是一个来自小鼠的综合单细胞RNA测序资源.
  • 在不同的细胞子集中比较年轻和老样本之间的基因表达特征.

主要成果:

  • 观察到一种普遍的"相反的衰老效应",其中基因表达在某些细胞子集中增加,而在其他细胞中减少.
  • 这种效应在与核糖体功能和翻译相关的基因中显著丰富.
  • 转录组多样性,通过基因计数和香农度来衡量,也表现出这种相反的衰老模式.

结论:

  • 衰老对基因表达的影响复杂且特定于细胞子集.
  • 针对与衰老相关的基因的干预措施必须考虑这些细胞特异性表达变化.
关键词:
衰老的衰老 衰老的衰老生物信息学是一种生物信息学.一个单细胞RNA-seqq.

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