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相关概念视频

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Cryopreserving and Recovering of Human iPS Cells using Complete KnockOut Serum Replacement Feeder-Free Medium
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在抑郁症中诱导多能干细胞 (iPSC) 技术.

Apurva Kumar1, Laura Stertz1, Antonio L Teixeira2,3

  • 1Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Advances in experimental medicine and biology
|September 11, 2024
PubMed
概括

诱导多能干细胞 (iPSCs) 为重大抑郁症 (MDD) 研究提供了一种新的体外方法. 本章详细介绍了iPSC应用,3D有机体模型和干细胞疗法,用于MDD治疗潜力.

关键词:
抑郁症 抑郁症 抑郁症神经新生是什么意思 神经新生是什么意思器官类动物 器官类动物干细胞是一种干细胞.这就是 iPSC 的意义.

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科学领域:

  • 神经科学是一个神经科学.
  • 干细胞生物学 干细胞生物学
  • 精神病学是一个精神病学.

背景情况:

  • 大型抑郁症 (MDD) 仍然是一个重大的全球健康挑战.
  • 目前对MDD的治疗策略在有效性和副作用方面存在局限性.
  • 诱导多能干细胞 (iPSCs) 为模拟和治疗MDD提供了一个新的途径.

研究的目的:

  • 探索iPSC技术在了解和治疗MDD方面的实用性.
  • 审查从iPSC获得的3D有机体模型在MDD研究中的应用.
  • 在MDD的背景下讨论介质干细胞 (MSC) 治疗的潜力.

主要方法:

  • 使用iPSC技术生成患者特定的细胞模型.
  • 开发和使用3D有机体系统进行MDD的体外研究.
  • 在临床前MDD模型中研究MSCs的治疗效果.

主要成果:

  • iPSCs可以实现个性化药物查和MDD的疾病建模.
  • 三维有机体模型概述了MDD病理生理学的关键方面.
  • 在MDD中,MSC疗法对神经保护和情绪调节有前途.

结论:

  • 基于iPSC的方法,包括3D器官,为推进MDD研究和精确精神病学提供了强大的工具.
  • 介酶干细胞疗法为MDD提供了潜在的治疗策略.
  • 需要进一步的研究才能充分实现这些创新技术对MDD的临床潜力.