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微生物介导的性催化剂在正常细胞系和腺癌细胞系中具有差异性的复苏保护作用

Brian Óg Murphy¹, Cheryl Latimer¹, Sara Dobani¹

¹Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, UK.

International journal of food sciences and nutrition

|September 11, 2024

概括

来自肠道微生物的代谢物可以保护结肠细胞免受DNA损伤. 这些化合物激活Nrf2-ARE通路,为减少与衰老相关的癌症风险提供了潜在的策略.

科学领域:

细胞和分子生物学细胞和分子生物学
遗传学是一个遗传学.
癌症研究癌症研究

背景情况:

衰老与减少Nrf2活性和DNA修复有关,增加癌症风险.
累积的DNA损伤是与年龄相关的癌症发展的关键因素.
(多) 及其微生物代谢物显示出减少DNA损伤的潜力.

研究的目的:

为了研究四种来自结肠微生物群的性催化剂的复苏保护作用.
为了确定这些代谢物的对Nrf2-抗氧化剂反应元素 (ARE) 途径的影响.
评估它们在正常和癌症结肠细胞细胞系中的有效性.

主要方法:

使用了正常 (CCD 841 CoN) 和腺癌 (HT29) 大肠细胞细胞系.
暴露细胞的过氧化 (H2O2) 诱导氧化DNA损伤.
评估了性催化剂降低DNA损伤和调节Nrf2-ARE通路基因的能力.

主要成果:

所有四种性催化剂都表现出显著的复苏保护活性 (p < .001).
这些代谢产物有效调节Nrf2-ARE通路内的关键基因.
在生理学上相关的度下,在正常细胞和腺癌细胞中观察到DNA损伤的减少.

结论:

来自结肠的类代谢物显示出对抗氧化DNA损伤的显著复苏保护作用.
这些代谢物调节Nrf2-ARE通路,有助于它们的保护功能.
这表明一种潜在的治疗策略,可以缓解与年龄相关的DNA损伤和癌症风险.

关键词:

3-(3′-基) 氨酸是氨酸中的一种.3 - ) 氨酸是3 - ) 氨酸中的一种.4 - 基烯酸是4 - 基烯酸.青酸是什么青酸是什么在COMET测试中进行了测试.结肠细胞结肠细胞

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