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Updated: Jun 13, 2025

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通过末端连接机制进行RNA介导的双链断裂修复

Youngkyu Jeon1,2, Yilin Lu1, Margherita Maria Ferrari3,4

  • 1School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

Nature communications
|September 11, 2024
PubMed
概括

转录RNA直接影响DNA双链断裂 (DSB) 修复途径,如非同源端连接 (NHEJ) 和微同源介导端连接 (MMEJ). 序列互补性引导RNA促进或抑制DSB修复,影响基因组稳定性.

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