在初级实践中,在急性SARS-CoV-2感染后的症状负担,凝血病和心脏病
Roisin Colleran1,2, Sean Fitzgerald1, Himanshu Rai1,2
1Cardiovascular Research Institute (CVRI) Dublin, Mater Private Network, Dublin, Ireland.
持续的症状和异常的凝血标记在COVID-19感染后很常见,即使在MRI上心脏异常较少,与医院研究相比. 这突显了SARS-CoV-2后持续存在的健康问题.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 包括心脏和免疫影响在内的SARS-CoV-2感染的长期影响需要进一步调查.
- 了解COVID-19后的持续症状和凝血异常对于患者管理至关重要.
研究的目的:
- 在初级保健机构中调查COVID-19后的症状负担和心脏异常.
- 为了将心脏发现与免疫反应和凝血的生物标志物相关联.
- 为了将结果与之前在医院环境中的研究进行比较.
主要方法:
- 在临床试验.gov (NCT04823182) 注册的前性,单臂观察性横截面研究 (SETANTA).
- 招募了100名近期COVID-19患者 (感染后6周至12个月).
- 通过心磁共振成像 (CMR) 评估心脏功能,并分析免疫反应和凝血病的生物标志物.
主要成果:
- 83%的参与者报告了持续的症状;96%的人有SARS-CoV-2的阳性血清学.
- 心脏异常:晚期加多增强 (2.2%),心周溢出 (8.3%),喷射率降低 (17.4%).
- 凝血异常:高威尔布兰德因子抗原 (32.7%),高纤维素 (10.2%),高D-Dimer (11.1%). 凝血异常:高威尔布兰德因子抗原 (32.7%),高纤维素 (10.2%),高D-Dimer (11.1%).
结论:
- 在COVID-19后的初级保健患者中观察到的持续症状和异常凝血标志物的高患病率.
- 与医院研究相比,CMR异常的频率较低表明患者群体或疾病严重程度的潜在差异.
- 需要进一步的研究来了解这些发现的长期影响.
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