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Updated: Jun 13, 2025

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry
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Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

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揭示了 sol g 2.1 蛋白质和潜在的连接体结合的pH取决于形状的变化

Siriporn Nonkhwao1,2, Doungkamol Leaokittikul1, Rina Patramanon3,2

  • 1Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.

Scientific reports
|September 11, 2024
PubMed
概括

Sol g 2.1 火毒素中的蛋白质在中性pH下最好地结合疏水分子. 分子模拟证实了在pH7.4下更高的亲和力和稳定性,表明其作为pH响应药物递送载体的潜力.

关键词:
分子动力学模拟的模拟.由PH诱导的连接物释放.费洛蒙结合蛋白 (PBPs) 是一种结合蛋白质连体的结合毒素蛋白质Solg 2.1 2.1 是一个有毒的蛋白质.

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