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吸烟状态对血清与美国成年人因特定原因死亡率之间的关系的影响
Gege Jiang1, Shangqi Sun2, Liqin Huang1
1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Scientific reports
|September 11, 2024
概括
是一种抗氧化剂,与死亡率有着复杂的关系. 虽然中等水平可能会降低死亡风险,但高度,特别是在吸烟者中,可能会增加死亡风险,突出显示值效应.
科学领域:
- 营养生物化学 营养生物化学
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 是一种重要的抗氧化剂,与死亡率有记录的联系.
- 在一般人群中,含量与死亡率之间的确切关联需要进一步阐明.
研究的目的:
- 调查血清度与所有原因和特定原因死亡率之间的关系.
- 探索潜在的值效应,并确定与水平和死亡率相关的风险因素,如吸烟.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2003-2004,2011-2016) 中对5449名参与者的分析.
- 使用了COX比例危险模型,Kaplan-Meier生存分析和受限制的立方脊柱回归.
- 根据年龄,性别和吸烟状况进行了子组分析.
主要成果:
- 中等血清度 (第二和第三四分位数) 与所有原因,非心血管和心血管死亡率的降低有关.
- 较高的含量 (≤129.82μg/L对于任何原因/非心血管疾病,≤129.08μg/L对于心血管疾病) 显示出保护作用.
- 高血清 (≥129.82μg/L) 与目前吸烟者的全因死亡率正相关,表明潜在的风险增加.
结论:
- 血清对死亡率的保护作用表现为剂量依赖的模式,在较高度下,益处会减少.
- 血清的度可能会增加死亡风险,特别是所有原因的死亡率,在超过特定值的现有吸烟者中.
- 这些发现强调了考虑最佳摄入范围和个人风险因素 (如吸烟状况) 与死亡结果相关的重要性.
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