双胞胎之间的生活方式差异与其内部和外部曝光体谱的相似性降低有关
Gabin Drouard1, Zhiyang Wang2, Aino Heikkinen2
1Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. gabin.drouard@helsinki.fi.
Scientific reports
|September 11, 2024
概括
双胞胎之间的生活方式差异与它们的内部和外部暴露组概况相关. 行为和物质使用的较大差异与相似性较差的暴露组概况有关,特别是在过度饮酒时.
科学领域:
- 环境健康 环境健康
- 遗传学 遗传学 是一个
- 生物标志物 生物标志物
背景情况:
- 生活方式变化与个体暴露组概况之间的关系尚未得到充分理解.
- 调查共同双胞胎有助于控制遗传和家族因素.
研究的目的:
- 检查双胞胎共同生活方式的差异是否与其内部和外部曝光体形状的差异有关.
- 探索exposome领域和生活方式行为之间的联系.
主要方法:
- 分析了257个年轻成年同性双胞胎对的暴露组 (外部,蛋白质组,代谢组,表观遗传年龄加速) 概况.
- 使用高斯相似性来评估对内概况相似性.
- 相关的生活方式差异与暴露组特征差异.
主要成果:
- 共同双胞胎暴露基因的较低相似性与行为和物质使用的较大差异相关.
- 过度饮酒行为与外部暴露组的关联最强.
- 调查结果突出了社会行为,物质使用和暴露组个人资料之间的联系.
结论:
- 生活方式,特别是物质使用和社会行为,显著影响了内部和外部的暴露组形状.
- 双胞胎研究提供了一个强大的模型,用于剖析暴露组的环境和行为影响.
- 结果强调了行为,环境和生物特征的相互联系.
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