双边损伤对自发高血压大鼠的开放循环巴罗反射功能和尿液分泌的影响
Toru Kawada1, Masafumi Fukumitsu2, Hiroki Matsushita2
1Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan. torukawa@ncvc.go.jp.
概括
在自发高血压的老鼠中,双边损 (RDN) 在血压变化期间改善了尿液输出调节. 这表明RDN可能会增强脏功能控制,独立于血管素II.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管生理学心血管生理学
- 高血压研究 高血压研究
背景情况:
- 众所周知,双边缺血 (RDN) 降低了动脉压 (AP) 并延迟了自发高血压大鼠 (SHR) 的高血压.
- 在巴罗反射介导的AP波动期间,RDN对尿量调节的影响尚不清楚.
- 了解交感神经活动在尿液输出中的作用,对于管理高血压至关重要.
研究的目的:
- 研究双边RDN如何影响SHR中动脉压和正常化尿流 (nUF) 之间的关系.
- 评估telmisartan的影响,一个血管激素II类型1受体阻断剂,在AP-nUF关系后RDN.
- 确定交感神经活动与血管新生素II在调节功能中的相互作用.
主要方法:
- 量化了接受双边RDN和假冒操作的SHR中AP和nUF之间的关系.
- 服用泰尔米沙坦 (2.5 mg/kg),以评估其对AP-nUF关系的急性影响.
- 分析了nUF与平均AP的斜率变化,以评估尿液输出功能.
主要成果:
- 双边RDN降低了AP并缩小了巴罗反射反应范围.
- 与虚假 (0.076 ± 0.045) 相比,RDN组的nUF与平均AP的斜率较高 (0.188 ± 0.039),表明尿液输出调节得到改善 (P = 0.059).
- 泰尔米沙坦显著增加了两组的nUF斜率 (假:0.285 ± 0.034; RDN:0.416 ± 0.078),突出了血管激素II的作用.
结论:
- 双边RDN可能会提高自发高血压大鼠的尿量可控性.
- 研究结果表明,损伤会影响功能,而不依赖于正在进行的交感神经活动.
- ангиотензин II 显著促进尿液输出调节,不论交感神经活动水平.
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