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Updated: Jun 13, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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在DNA末端切除和DNA保护中的BRCA1-BARD1功能机制

Ilaria Ceppi1, Maria Rosaria Dello Stritto1, Martin Mütze2

  • 1Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Bellinzona, Switzerland.

Nature
|September 11, 2024
PubMed
概括

该BRCA1-BARD1复合体直接促进DNA末端切除以修复双链断裂. 在RAD51的存在下,其功能转移到DNA保护,平衡修复和复制叉稳定性.

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