大脑与肠道之间的信号控制肠道脂肪的吸收
Qianqian Lyu1,2, Wenzhi Xue1,3, Ruixin Liu1,2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
大脑
科学领域:
- 神经科学
- 胃肠病学
- 药理学
背景情况:
- 食物中的脂肪是能量必需的, 但过量摄入会导致肥胖.
- 肠道脂肪吸收主要通过扩散发生.
- 大脑-肠轴在脂肪吸收中的作用尚不清楚.
研究的目的:
- 研究迷路背部运动核 (DMV) 在调节肠道脂肪吸收中的作用.
- 确定DMV影响脂肪吸收的机制.
- 探索向DMV - 阴道通路的治疗潜力,以控制体重.
主要方法:
- 在动物模型中DMV神经元的无活化和激活.
- 小的长度和脂肪吸收的分析.
- 使用光亲和标记和冷电子显微镜对GABAA受体结合的识别和结构分析.
- 有条件的Gabra1在DMV.
主要成果:
- DMV神经元失活减少了肠道脂肪的吸收,并导致体重减轻.
- DMV神经元的激活增加了脂肪的吸收和体重增加.
- 向向阴投射的特定DMV神经元缩短了微,减少了脂肪吸收.
- 这种天然化合物抑制了DMV - 阴道通路,减少了脂肪吸收.
- 普埃拉林与GABAA受体上的异质部位结合.
- 在DMV中Gabra1的条件淘汰在很大程度上阻断了puerarin对脂肪吸收的影响.
结论:
- 迷路的背部运动核 (DMV) 是通过大脑-肠轴吸收肠道脂肪的关键调节器.
- 通过缩短微来抑制DMV - 阴道 - 阴轴的脂肪吸收.
- 通过DMV中的GABAA受体起作用,为控制脂肪吸收和促进体重减轻提供了潜在的治疗策略.
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