周围白细胞计数轨迹在更年期左右:一个前性队列研究
Qiaoyun Dai1, Yaya Zhang2,3, Xiujuan Zhao2,3
1National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China.
BMC women's health
|September 11, 2024
概括
更年期改变了周围白细胞 (WBC) 计数,中性粒细胞,淋巴细胞和单细胞的不同轨迹. 年龄和BMI显著影响这些变化,突出了免疫健康干预的关键窗口.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 更年期显著影响免疫系统,增加更年期后妇女对感染的易感性.
- 在更年期过渡期间,外周白细胞 (WBC) 计数的具体变化尚不清楚.
- 了解这些免疫转变对于管理绝经后妇女健康至关重要.
研究的目的:
- 为了研究周围白细胞 (WBC) 数量在最后的月经周期 (FMP) 周围的纵向变化.
- 检查年龄和体重指数 (BMI) 对更年期期间白细胞计数轨迹的影响.
- 确定在中年妇女中促进免疫健康的潜在窗口.
主要方法:
- 对3632名中国妇女进行了前性纵向队列研究,在12年内重复测量WBC指标 (TWBC,NEUT,LYM,MON).
- 多变量混合效应回归模型分析了与FMP相对的WBC计数变化.
- 相互作用和子组分析探讨了基线年龄和BMI对WBC轨迹的影响.
主要成果:
- 周围WBC数量,包括总WBC (TWBC),中性粒细胞 (NEUT) 和单细胞 (MON),在FMP后的2年内持续下降.
- 淋巴细胞 (LYM) 和NEUT在FMP附近呈现下降,而TWBC和MON在FMP后的2年内增加.
- 年龄和BMI与更年期阶段相互作用,改变WBC轨迹,高BMI可能会推迟或抵消更年期对TWBC和LYM的影响.
结论:
- 更年期与周围白细胞计数的显著和差异性变化有关.
- 年龄和BMI是调节更年期周围白细胞计数轨迹的关键因素.
- 更年期过渡为实施提高妇女免疫健康的战略提供了潜在的机会.
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