在儿科心脏病学中对经验范科米辛剂量指南的评估
Yousif S Alakeel1,2,3,4, Yazeed Alahmed5,6, Ghadah Alanazi7,5
1Department Pharmaceutical Care Services, King Abdulaziz Medical City, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. alakeely@gmail.com.
BMC pediatrics
|September 11, 2024
概括
由于耐药性,使用更高的万科米辛剂量. 这项研究发现,目前的儿童心脏病学范科米辛的剂量指南导致婴儿,幼儿和接受心肺旁路手术的人的治疗水平低.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 越来越多的细菌耐药性需要更高的万科米辛剂量.
- 对儿童心脏病患者评估当前的万科米辛剂量指南至关重要.
研究的目的:
- 评估儿童心脏病学中已建立的万科米辛药物管理指南 (MAG) 的有效性和安全性.
- 为了确定当前的销售许可证是否能在年轻的心脏病患者中达到治疗性万科米辛血清度.
主要方法:
- 从2020年6月到2021年3月进行了一项单中心前性队列研究.
- 包括14岁以下的儿科心脏病患者,至少三天内静脉注射万科米辛 (40毫克/公斤/天每6-8小时)
- 监测了血清中的万科米辛水平,以评估治疗范围的实现.
主要成果:
- 在88名患者中,71.6%的患者达到治疗性万科米辛水平 (7-20 mg/L).
- 婴儿 (29.2%),幼儿 (54.2%) 和接受心肺绕道手术 (CPB) 的患者 (87.5%) 的治疗水平较高.
- 8名 (10%) 患者血清肌素 (SCr) 升高,2名 (2.5%) 患有急性损伤 (AKI);使用 ACE 抑制剂与较低的SCr升高发生率有关.
结论:
- 目前的万科米辛药物管理指南 (MAG) 导致婴儿,幼儿和CPB患者的血清度低于治疗水平.
- 对预防急性损伤 (AKI) 的策略进行进一步调查是有必要的,因为原因仍未确定.
- 这项研究强调了针对特定儿科心脏病患者群体优化万科米辛剂量的潜在挑战.
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