可拆卸假肢穿戴和肺炎之间的关联:系统性审查和元分析
Tong Wah Lim1, Kar Yan Li2, Michael Francis Burrow1
1Division of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Pok Fu Lam, Hong Kong, Hong Kong SAR.
可拆卸假肢的磨损可能与呼吸道感染有关. 然而,本次审查没有从非随机化研究中找到确的证据来支持假肢穿戴作为肺炎风险因素.
科学领域:
- 口腔健康和传染病
- 公共卫生和流行病学
背景情况:
- 呼吸道病原体殖民于可拆卸假肢表面,这表明与呼吸道感染的潜在联系.
- 可拆卸假肢在呼吸道感染中的作用需要进一步研究.
研究的目的:
- 系统地审查和分析评估可拆卸假肢穿戴者和呼吸道感染之间的关联的临床研究.
- 评估关于可拆卸假肢磨损作为肺炎风险因素的证据.
主要方法:
- 六项非随机临床研究的系统审查和元分析.
- 在五个数据库中进行文献搜索,截至2024年5月.
- 使用纽卡斯尔-太华尺度进行质量评估,使用GRADE进行证据确定性.
主要成果:
- 假肢佩戴者肺炎的总概率为1.43 (随机效应) 和1.27 (固定效应).
- 观察到大量的异质性,但在前性研究中减少了.
- 对假肢佩戴者发展肺炎的证据确定性低至非常低.
结论:
- 非随机的临床研究没有提供确的证据表明假肢穿戴是肺炎的危险因素.
- 需要进一步进行高质量的研究来澄清这种关联.
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