常规脚-手腕指数 (ABI) 测量:在被诊断患有癌症的患者中,为动脉样硬化和早期左心室功能障碍提供了一个窗口
Netanel Golan1,2, Rafael Y Brzezinski1,3, Moaad Slieman1,3
1Department of Cardiology, Tel Aviv Medical Center, 6 Weizmann Street, Tel Aviv, Israel.
Cardio-oncology (London, England)
|September 11, 2024
概括
在癌症患者中,常规的脚-手腕指数 (ABI) 测试显示了与左心室 (LV) 功能障碍的相关性. 这种廉价的测试可以帮助早期检测动脉样硬化和心脏毒性.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 血管医学 血管医学
背景情况:
- 癌症疗法可以加速缺血.
- 脚-手腕指数 (ABI) 是一种简单,具有成本效益的测试,用于检测周围动脉疾病 (PAD),但未得到充分利用.
- 该研究调查了癌症患者的常规ABI,以评估PAD及其与左心室 (LV) 功能障碍的联系.
研究的目的:
- 评估常规ABI测量在癌症患者PAD诊断中的作用.
- 为了确定ABI是否与LV功能障碍相关,定义为LV全球纵向应变 (GLS) <19%.
- 探索减少ABI,LV功能障碍和全因死亡率之间的关联.
主要方法:
- 对226名癌症患者进行了回顾性单中心研究.
- 纳入标准:常规的ABI和LV GLS心声学.
- 主要终点:PAD患病率和与LV功能障碍的相关性;次要终点:与死亡率相关.
主要成果:
- 周围动脉疾病 (PAD) 在6%的患者中被诊断出.
- 在ABI和LV GLS之间发现了显著的正相关性 (r=0.22,p<0.01).
- 减少LV GLS的患者平均ABI较低;死亡率组观察到ABI减少,但不显著.
结论:
- 癌症患者的常规ABI测试首次报告.
- ABI与LV GLS有显著的相关性,这表明它有可能用于早期动脉样硬化和心脏毒性检测.
- 建议进一步进行前性试验,以将ABI纳入常规癌症患者评估中.
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