高密度脂蛋白胆固醇轨迹和新发代谢功能障碍相关的脂肪肝疾病发病率:一项纵向研究
Mengting Zhang1,2, Dongchun Chang2, Qing Guan2
1Department of Gastroenterology, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.
持续低高密度脂蛋白胆固醇 (HDL-C) 水平显著增加患有代谢功能障碍相关脂肪肝疾病 (MAFLD) 的风险. 监测HDL-C和干预下降对于预防MAFLD至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 高密度脂蛋白胆固醇 (HDL-C) 影响代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的发展.
- 动态HDL-C变化与MAFLD风险之间的关联尚未得到充分理解.
研究的目的:
- 研究HDL-C轨迹与新发性MAFLD之间的关系.
- 为个性化MAFLD预防策略提供基础.
主要方法:
- 利用基于小组的轨迹模型在1507名参与者中识别HDL-C模式.
- 采用Cox比例危险回归来评估与不同高密度血清-C轨迹相关的MAFLD风险.
- 在2022年对MAFLD发病率进行了跟进.
主要成果:
- 随着HDL-C稳定性增加,MAFLD发病率下降 (低稳定组的26.5%,高稳定组的2.6%).
- 与高稳定的HDL-C相比,持久低的HDL-C与5.421倍增加的MAFLD风险有关.
- 亚组分析表明,性别,年龄或超重/肥胖对这种关联没有显著的影响.
结论:
- 持续低的HDL-C水平是MAFLD发病的重要危险因素.
- 长期监测HDL-C和及时干预下降水平对于预防MAFLD至关重要.
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