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相关概念视频

Autism Spectrum Disorder01:19

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Modeling in Therapy01:26

Modeling in Therapy

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Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
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相关实验视频

Updated: Jun 13, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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在自闭症中,合同功能连接概况在自闭症中.

Clara F Weber1,2,3, Valeria Kebets1, Oualid Benkarim1

  • 1Multimodal Imaging and Connectome Analysis Laboratory, McConnell Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Molecular autism
|September 11, 2024
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概括

自闭症谱系障碍 (ASD) 与大脑连接的改变有关,这项研究发现,ASD患者的长距离连接减少,短距离连接增加. 这些通过连接距离 (CD) 测量的连接性变化似乎是ASD的稳定成像生物标志物.

关键词:
自闭症谱系障碍 自闭症谱系障碍连接中断 连接中断进行距离分析.功能连接性的功能连接性.磁共振成像技术 磁共振成像技术神经发育障碍 神经发育障碍

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Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
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相关实验视频

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科学领域:

  • 神经科学是一个神经科学.
  • 脑部成像 脑部成像
  • 发育障碍 发育障碍 发展障碍

背景情况:

  • 自闭症谱系障碍 (ASD) 是一种神经发育状况,其特征是异常的大脑网络组织.
  • 以前的研究表明,自闭症患者的功能连接性改变可能会随连接长度而变化.

研究的目的:

  • 调查ASD中的功能性连接病变是否与远距离与短距离功能连接中断有关.
  • 检查连接距离 (CD) 与宏观网络,微型架构和ASD中的临床表型之间的关系.

主要方法:

  • 使用了ABIDE-I数据集,包括103名患有自闭症的男性和108名神经类型对照 (NT).
  • 通过使用地理距离映射和静止状态功能连接来计算大脑皮层范围连接距离 (CD) 测量.
  • 在ASD和NT组之间比较CD,分析与年龄,症状严重程度和智商的关联,并探索与皮层梯度和细胞架构的关系.

主要成果:

  • 与NT对照组相比,ASD参与者在CD中表现出广泛的减少,表明平均连接长度较短.
  • 这些减少表明ASD的远程连接性下降,而短程连接性增加,特别是在跨运输系统中.
  • 与ASD相关的CD减少在年龄和症状严重程度上是一致的,并且与智商得分呈正相关.

结论:

  • 连接距离 (CD) 的减少代表了ASD中稳定的成像表型,主要影响着对边缘和异模关联系统.
  • 这些发现支持了之前关于ASD中短距离过度连接和远距离不足连接之间的不平衡的报告.
  • 这项研究强调CD作为一种潜在的生物标志物,用于理解ASD中大脑网络组织.