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老年人营养风险指数和老年人的认知功能与/或没有慢性病之间的关联
Shan Wang1, Jiajia Zhang1, Jiaru Zhuang1
1Obstetrics, Gynecology and Reproduction Research, Affiliated Hospital of Jiangnan University, Wuxi, P. R. China.
Brain and behavior
|September 12, 2024
概括
通过老年营养风险指数 (GNRI) 测量较高的营养状况,与老年人,包括慢性病患者 (CKD) 的更好的认知功能有关. 改善营养可能有助于预防认知能力下降.
科学领域:
- 老年医学 老年医学
- 营养科学 营养科学
- 神经科学是一个神经科学.
背景情况:
- 认知障碍在慢性病 (CKD) 患者中很常见.
- 患有CKD的老年人患有认知能力下降的风险较高.
- 营养状况是影响认知健康的潜在因素.
研究的目的:
- 研究老年营养风险指数 (GNRI) 与认知功能之间的关联.
- 为了检查老年人有或没有CKD的这种关系.
- 确定预防认知衰退的营养策略.
主要方法:
- 来自2011-2014年国家健康和营养检查调查 (NHANES) 的2728名参与者的分析.
- 认知功能使用CERAD Word Learning,动物流利性,数字符号替换和全球z-score进行评估.
- 老年人营养风险指数 (GNRI) 由血清白蛋白,体重和理想体重计算.
- 进行了加权多重线性回归和子组分析.
主要成果:
- 在更高的GNRI和认知功能之间发现了显著的积极关联 (全球z-score:β=0.01;95%CI [0.00,0.01]).
- 这种关联在各种子组中是一致的,包括不同的性别,年龄和健康状况.
- 在GNRI和认知功能之间观察到线性关系,没有发现显著的相互作用.
结论:
- 较高的营养状况,由GNRI表示,与老年人的认知健康有积极的关联,无论CKD状态如何.
- 提高老年人的营养状况可能是缓解认知衰退的关键策略.
- 研究结果强调了营养在维持不同健康人群的认知功能的重要性.
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