[高血压患者的勃起功能障碍]
Agnese Vella1, Kevin Dobretz1, Massimo Valerio2
1Cardiologie préventive, Service de cardiologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Revue medicale suisse
|September 12, 2024
概括
勃起功能障碍影响20-25%的高血压患者,通常是由于动脉样硬化. 管理包括生活方式的改变,首选的抗高血压药物如ARB和ACE抑制剂和PDE5抑制剂,同时避免某些利尿剂和β抑制剂.
科学领域:
- 心脏病学 心脏病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
背景情况:
- 勃起功能障碍 (ED) 是高血压患者常见的并发症,影响该人口的20-25%.
- 高血压患者的ED通常意味着潜在的动脉样硬化,这是一个需要综合管理的全身性疾病.
- 目前对ED高血压患者的治疗策略包括改变生活方式和药理干预.
研究的目的:
- 概述高血压患者勃起功能障碍的最佳管理策略.
- 为了确定有益或有害于勃起功能的抗高血压药物.
- 讨论固酶5型抑制剂在治疗ED患者中的作用.
主要方法:
- 关于高血压,勃起功能障碍和动脉样硬化的当前医学文献的综述.
- 对高血压的药理疗法的分析,重点关注它们对勃起功能的影响.
- 评估生活方式干预措施及其对高血压和ED的影响.
主要成果:
- ангиотензин 2 受体对抗剂,ACE 抑制剂,通道阻断剂和 nebivolol 是首选的抗高血压药物.
- 一般应避免使用 thiazide 和 thiazide 类利尿剂 (除了 indapamide),传统的β 阻断剂和中央抗高血压剂.
- 5型固酶抑制剂是治疗高血压男性ED的有效药理选择.
结论:
- 定制抗高血压治疗对于高血压患者的ED管理至关重要.
- 特定的抗高血压药物类别表明对勃起功能有有利或不利的影响.
- 优化抗高血压治疗,生活方式改变和PDE5抑制剂的组合为高血压患者的ED管理提供了全面的方法.
相关概念视频
01:28Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
136
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
136
01:20Disorders of the Male Reproductive System
358
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
358
01:23Antihypertensive Drugs: Vasodilators
491
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
491
01:18Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
398
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
398
01:28Special considerations while measuring blood pressure
710
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
710