人工重力:对微重力诱导的向前流体移动的有效对策?
Larry A Kramer1, Khader M Hasan1, Xu Zhang2
1Department of Diagnostic Imaging and Intervention, McGovern Medical School, UTHealth Houston, Houston, Texas, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|September 12, 2024
概括
每日人工重力 (AG) 疗程并没有缓解太空飞行引起的内液位移. 简短的AG暴露不足以抵消模拟微重力时向前的流体移动,这表明需要更长的持续时间或更强的力.
科学领域:
- 空间生理学空间生理学
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 长时间的太空飞行会导致内体积变化,这与微重力诱导的向前流体移动有关.
- 这些变化可能会导致与太空飞行相关的神经眼综合征.
- 人工引力 (AG) 被探索为一种潜在的对策.
研究的目的:
- 调查每日人工重力 (AG) 课程是否可以在模拟的向前流体转移过程中减轻内病理生理效应.
- 评估间歇性和连续性AG作为对策的有效性.
主要方法:
- 24名健康的志愿者接受了60天的6°向下倾斜的卧床休息 (HDTBR).
- 被试被随机分为三个组:没有AG (控制),每日30分钟间歇性AG (iAG) 或每天30分钟连续的AG (cAG).
- 内体积测量,内动脉血动力学和脑脊液流量使用3TMRI进行测量.
主要成果:
- HDTBR诱导了内体积和脑脊液流速的显著增加,并降低了52日内动脉中风体积和流速.
- 内动脉阻力指数在第14天增加,但后来恢复正常.
- 无论是iAG还是cAG的干预都没有显著改变这些由HDTBR引起的变化,这表明缓解不足.
结论:
- 每天30分钟的AG暴露不足以抵消HDTBR模拟的内液位移.
- 未来的研究应该探索更长的AG会议持续时间或更高的重力.
- 优化的AG协议可能是必要的,以防止太空飞行相关的神经眼综合征.
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