视觉幻觉与三氧化物治疗在急性原肌细胞白血病的视觉幻觉
Himil J Mahadevia1, Ammar Al-Obaidi2, Furha Cossor3
1Internal Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.
Cureus
|September 12, 2024
概括
这份病例报告详细介绍了一名患有急性肌肉细胞白血病的患者,他在三氧化治疗期间经历了严重的视觉幻觉. 这突显了的罕见神经毒性,需要对患者进行仔细监测.
科学领域:
- 血液学 血液学 血液学
- 神经瘤学神经瘤学
- 毒理学 毒理学 毒理学
背景情况:
- 急性肌肉细胞白血病 (APML) 是急性肌肉细胞白血病的一个独特的亚型.
- 对APML的标准治疗包括全转网红酸 (ATRA) 和三氧化.
- 三氧化物在治疗剂量下通常耐受良好.
研究的目的:
- 报告一个不寻常的毒性病例.
- 在接受三氧化治疗APML的患者中描述严重的神经症状,特别是视觉幻觉.
- 强调在APML治疗期间监测罕见毒性的重要性.
主要方法:
- 一个68岁的男性患有APML的病例报告.
- 患者接受了ATRA和三氧化的诱导和巩固疗法.
- 对神经症状的临床观察和治疗调整.
主要成果:
- 患者出现视力模糊,神经病变恶化和视觉幻觉.
- 在停止三氧化治疗后症状消失.
- 头部成像和常规实验室没有什么特别的.
- 这代表了三氧化物在治疗剂量的以前未报告的神经毒性.
结论:
- 三氧化物,即使在较低的治疗剂量下,也可能导致显著的神经毒性.
- 视觉幻觉和感官知觉改变是潜在的罕见副作用.
- 密切监测和患者教育关于治疗的潜在罕见毒性至关重要.
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