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在高脂肪饮食下,大豆油通过脑肠轴诱导神经炎症反应

Xiangyan Liu¹, Ran Tao¹, Fangrui Guo¹

¹Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.

Journal of traditional and complementary medicine

|September 12, 2024

概括

饮食中的脂肪摄入会影响神经炎症. 在小鼠中,大豆油的高消费加剧了大脑炎症和肠道屏障损伤,而不是油脂,这表明油脂可能是一个更健康的选择.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

神经炎症是神经退行性疾病的一个关键因素.
饮食中的脂肪摄入量和肠道健康与大脑疾病有关.
了解不同饮食脂肪对神经炎症的影响至关重要.

研究的目的:

研究油脂和大豆油对神经炎症和大脑肠道屏障完整性的差异性影响.
探索潜在的分子机制,包括炎症途径和肠道微生物群的变化.

主要方法:

一项为期20周的饮食干预研究,使用C57BL/6J小鼠食油或大豆油,脂肪能量为15%和35%.
评估神经炎症标志物,大脑抗氧化能力和大脑肠道屏障完整性.
对肠道微生物群组成和TLR4/MyD88/NF-κB p65炎症通路的分析.

主要成果:

来自油脂和大豆油的35%脂肪能量水平诱导了炎症,而大豆油导致了更明显的神经炎症.
大豆油加剧了神经细胞结构的损伤,高调节了炎症因素,并降低了大脑的抗氧化能力.
观察到TLR4/MyD88/NF-κB p65通路的激活,大脑-肠道屏障的破坏,以及肠道微生物群的改变 (减少了Akkermansia和未分类的Lachnospiraceae,增加了Dubosiella),特别是与大豆油.

结论:

与油脂相比,高食脂肪水平的大豆油会诱导更严重的神经炎症和肠道屏障损伤.
黄油可能是一个比大豆油更健康的饮食脂肪选择,与神经炎症有关.
这些发现为关于选择脂肪以减轻神经炎症的饮食建议提供了基础.

关键词:

饮食中的脂肪.我们的肠道微生物群.拉德·拉德·拉德 (Lard Lard) 是一个神经炎症是一种神经炎症.豆油是大豆油中的一种.

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