在接受无改性电治疗的精神分裂患者的麻醉管理和认知功能中,普罗波的有效性
Jian Wang1, Zhi-Jie Wang1, Shan Xu1
1Department of Anesthesiology, The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou 510370, Guangdong, China.
American journal of translational research
|September 12, 2024
概括
普罗波与埃托米达结合,在接受改性电疗法 (MECT) 的精神分裂患者中改善了麻醉和认知功能. 这种组合还减少了恢复时间和不良反应,显示出高安全性和有效性.
科学领域:
- 麻醉学 麻醉学
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 精神分裂症的治疗通常涉及改性电疗法 (MECT).
- 麻醉剂的选择会影响MECT的有效性和患者的治疗结果.
- 优化麻醉对于患者的安全和MECT期间的认知保存至关重要.
研究的目的:
- 评估普罗波对精神分裂症患者进行MECT的麻醉疗效的影响.
- 评估普罗波对MECT期间认知功能和不良反应的影响.
- 为了在MECT中比较单独的埃托米达和埃托米达-普罗波福尔组合用于麻醉诱导的结果.
主要方法:
- 80名接受MECT治疗的精神分裂症患者的回顾性分析.
- 患者分为埃托米达 (对照) 和埃托米达- (观察) 组.
- 血液动力学参数,恢复时间,认知功能 (WAIS-RC),症状严重程度 (PANSS) 和不良事件的比较.
主要成果:
- 血液动力学参数 (SBP,DBP,HR,SaO2) 在两组之间没有显著差异.
- 埃托米达特-普罗波福尔组的自发呼吸恢复和清醒时间显著缩短.
- 观察组的认知功能有所改善 (WAIS-RC较高),症状严重程度降低 (PANSS较低),不良反应较少.
结论:
- 作为埃托米达的辅助剂,普罗波可以增强MECT对精神分裂症的麻醉结果.
- 这种组合有效地保护了认知功能,并减少了不良事件.
- 普罗波在MECT中显示出对麻醉诱导的高安全性和有效性.
更多相关视频
相关概念视频
01:30Electroconvulsive Therapy
29
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
29
01:26Psychosis: Goals of Pharmacotherapy
110
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
110
01:24Parenteral Anesthetics: Overview
111
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
111
01:20Antiepileptic Drugs: Potassium Channel Activators
149
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
149
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
343
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
343
01:28Psychosis and Antipsychotic Drugs: Overview
195
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
195