血清标志物的预测值,用于粘膜愈合在患有炎症性肠道疾病的患者
Lei Lei1, Ting Lv1, Lingling Wang1
1Department of Gastroenterology, No. 215 Hospital of Shaanxi Nuclear Industry No. 35 Weiyang West Road, Qindu District, Xianyang 712000, Shaanxi, China.
American journal of translational research
|September 12, 2024
概括
血清标记物,如白细胞计数和C反应蛋白,可以在炎症性肠病 (IBD) 中非侵入性预测粘膜的愈合. 这些标记物有助于评估疾病活性,并指导性结肠炎和克罗恩病患者的治疗.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),以慢性炎症为特征.
- 评估粘膜愈合 (MH) 对于有效的IBD管理至关重要,但内镜评估可能具有侵入性.
- 需要非侵入性生物标志物来监测IBD患者的疾病活性和治疗反应.
研究的目的:
- 评估血清炎症标志物在预测IBD患者的粘膜愈合 (MH) 中的有用性.
- 确定各种血清标志物的诊断准确性,以评估MH.
- 确定与IBD中未能达到MH相关的独立因素.
主要方法:
- 对320名IBD患者 (176名UC,144名CD) 和100名健康对照的回顾性分析.
- 测量血清白细胞 (WBC),血小板数 (PLT),C反应蛋白 (CRP),红细胞沉积率 (ESR),血小板/淋巴细胞比率 (PLR) 和中性粒细胞/淋巴细胞比率 (NLR).
- 统计分析包括单变量和多变量分析,以评估MH的诊断价值,并确定MH失败的风险因素.
主要成果:
- 与对照组相比,IBD患者的WBC,PLT,ESR,CRP,PLR和NLR水平显著更高 (P <0.05).与对照组相比,IBD患者的WBC,PLT,ESR,CRP,PLR和NLR水平显著更高.
- 获得MH的患者的这些标志物水平明显低于没有获得MH的患者 (P <0.05).
- 对于评估的标志物,诊断MH的AUC值在0.673到0.791之间. 高水平的WBC,PLT,ESR,CRP,PLR和NLR是未能达到MH的独立风险因素.
结论:
- 包括WBC,PLT,ESR,CRP,PLR和NLR在内的血清标记是IBD粘膜愈合的有价值的非侵入性预测剂.
- 这些标记物显示出在监测IBD患者时常规临床应用的潜力.
- 腹部疼痛和炎症标志物升高与IBD的粘膜愈合结果差相关.
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