2型糖尿病患者血清25-基维生素D水平与周围动脉疾病之间的相关性:单中心回顾性研究
Cila Zhou1, Bin Zhou1, Kuang Yao1
1Department of Metabolic Endocrinology, Shaoyang Central Hospital Shaoyang 422000, Hunan, China.
American journal of translational research
|September 12, 2024
概括
较低的维生素D水平与2型糖尿病患者患外围动脉疾病 (PAD) 的风险更高有关. 解决维生素D缺乏症可能有助于在这个患者群体中预防PAD.
科学领域:
- 内分泌学 在内分泌学.
- 血管医学 血管医学
- 营养科学 营养科学
背景情况:
- 2型糖尿病 (T2DM) 是心血管并发症的重要危险因素,包括周围动脉疾病 (PAD).
- 越来越多的人认为维生素D缺乏是导致各种慢性疾病的潜在因素.
研究的目的:
- 为了调查血清25-基维生素D (25(OH) D) 水平与被诊断为T2DM的患者中PAD的存在之间的关联.
- 为了在这个特定的患者群体中确定PAD的风险因素.
主要方法:
- 对752名T2DM患者进行了回顾性分析,比较了患有PAD和没有PAD的患者.
- 分析了人口统计数据,生化指数和脚-手臂指数 (ABI).
- 用皮尔森相关性和多变量逻辑回归来评估关系和风险因素,并使用ROC分析来预测价值.
主要成果:
- 与仅T2DM患者相比,T2DM和PAD患者年龄较大,糖尿病持续时间较长,BMI较低,ABI较低.
- 在T2DM+PAD组中观察到较低的血清25(OH) D水平显著.
- 较低的25OH) D水平,年龄较大,较低的BMI和较高的LDL-C是PAD的独立风险因素.
结论:
- 血清25(OH) D水平降低与T2DM患者的PAD风险增加有关.
- 早期发现和管理维生素D缺乏症可能对T2DM患者的PAD预防策略很重要.
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