母亲的高脂肪饮食改变了心脏发育期间的TET介导表观遗传调节
Yuhan Yang1, Logan Rivera1, Shaohai Fang1
1Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA.
iScience
|September 12, 2024
概括
母亲高脂肪饮食通过改变表观遗传学,导致胚胎心脏缺陷. 补充维生素C可以通过支持Tet酶活性和健康的胚胎发育来预防这些缺陷.
科学领域:
- 发育生物学是发展生物学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 营养科学 营养科学
背景情况:
- 不平衡的孕产妇营养,包括高脂肪饮食 (HFD),与不良的胚胎结果有关.
- 饮食不良导致的代谢压力会影响表观遗传调节器,导致先天性疾病.
研究的目的:
- 调查母亲HFD对胚胎心脏发育和表观遗传修饰的影响.
- 为了确定维生素C补充能否抵消HFD引起的发育缺陷.
主要方法:
- 在怀孕期间,小鼠被食HFD.
- 胚胎心脏组织分析了表观遗传标记 (5hmC) 和染色质可访问性.
- 评估了维生素C补充剂和基因修改的影响.
主要成果:
- 孕产妇HFD诱导了胚胎中的代谢变化和非紧缩性心肌病 (NCC).
- 在胚胎心脏中,HFD暴露降低了5-基甲基细胞素 (5hmC) 水平,并改变了染色质可访问性.
- 维生素C补充剂减轻了HFD的影响,恢复了Tet酶活性,并防止了NCC.
结论:
- 孕产妇的饮食成分极大地影响了胚胎表观遗传编程和心脏发育.
- 维生素C通过支持Tet酶功能,提供了对HFD诱导的发育性心脏毒性的保护作用.
- 均衡的孕产妇营养对于预防先天性心脏缺陷至关重要.
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