儿科肺结核和肺外结核的比较分析:叙利亚的一项单中心回顾性队列研究
Hussein Hamdar1, Ali Alakbar Nahle1, Jamal Ataya2
1Faculty of Medicine, Damascus University, Damascus, Syria.
Heliyon
|September 12, 2024
概括
外肺结核 (EPTB) 在住院的叙利亚儿童中比肺结核 (PTB) 更常见. EPTB,特别是结核病脑膜炎,与较高的死亡率有关,需要改善儿科结核病诊断和管理策略.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 仍然是一个重大的全球健康问题,导致大量的发病率和死亡率.
- 儿童结核病在诊断和管理方面存在独特的挑战,特别是在资源有限的环境中.
- 外肺结核 (EPTB) 通常比肺结核 (PTB) 有更复杂的表现.
研究的目的:
- 在叙利亚一家医院调查儿科结核病的流行病学,临床特征,诊断方法和早期死亡率.
- 在住院儿童中区分PTB和EPTB之间的特征和结果.
- 确定挑战,并为改善冲突受影响地区儿童结核病护理的战略提供信息.
主要方法:
- 叙利亚一所大学儿童医院对儿科结核病患者的回顾性队列研究 (2013年1月至2023年1月).
- 从医疗记录收集数据,包括人口统计,诊断,临床表现,胸部放射和结果.
- 使用SPSS版本25进行统计分析,以比较PTB和EPTB组.
主要成果:
- 129例儿童结核病例:26.4%PTB,73.6%EPTB (最常见的是淋巴,胃肠道).
- PTB患者更可能患上咳和异常的胸部X射线;EPTB患者更可能患有淋巴腺病.
- 总体死亡率14%,在EPTB (16.8%) 中更高,特别是结核病脑膜炎. 微生物学确认在PTB中更高.
结论:
- 在叙利亚的住院儿科结核病例中,EPTB占主导地位,造成诊断和管理的复杂性.
- 在EPTB中较高的死亡率强调了需要加强诊断和治疗策略的需要.
- 改善接触者追踪和对不同临床表现的认识对于儿童结核病诊断至关重要,特别是在具有挑战性的环境中.
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