相关实验视频

Updated: Jun 13, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

目前的见解和LncRNA Morrbid在疾病发病过程中的未来方向

Haiqiong Yang^1,2, Jiali Gao^3,4, Zaiyong Zheng^1,2

¹Department of Cardiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.

|September 12, 2024

概括

长非编码RNA Morrbid (lncRNA Morrbid) 在各种疾病中起作用. 本综述综合了关于lncRNA Morrbid的当前证据,解决了相互矛盾的发现及其治疗潜力.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
疾病机制疾病机制

背景情况:

非编码RNAs,包括长非编码RNAs (lncRNAs),是基因表达的关键调节者.
LncRNA Morrbid已经涉及到各种病理,包括瘤,心血管,炎症和代谢障碍.
现有关于lncRNA Morrbid的研究提出了相互矛盾的结论,需要全面的概述.

研究的目的:

全面审查和综合有关lncRNA Morrbid. 的当前文献.
讨论围绕lncRNA Morrbid. 的关键研究领域和争议.
为了评估 lncRNA Morrbid 作为潜在的治疗点.

主要方法:

对研究 lncRNA Morrbid. 的研究进行系统文献综述.
分析和讨论与lncRNA Morrbid在各种疾病中的作用相关的发现.
在现有研究机构中识别和检查有争议的结论.

主要成果:

LncRNA Morrbid与一系列疾病有关,包括癌症,心血管疾病,炎症和代谢失调.
在当前的文献中,关于lncRNA Morrbid的特定功能和影响存在显著的差异和矛盾.
该审查突出了有关lncRNA Morrbid生物作用的共识和辩论领域.

结论:

由于有相互矛盾的报道,深入了解lncRNA Morrbid多方面的作用至关重要.
需要进一步的研究来解决争议并澄清lncRNA Morrbid在疾病中的精确机制.
LncRNA Morrbid代表了一个有希望的,尽管复杂的,治疗干预的潜在目标.

关键词:

心血管疾病是什么心血管疾病这种LncRNA是病态的.长的非编码RNA是什么?在MIR4435-2HGG中使用.瘤是一个瘤.

更多相关视频

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...