女性单一和多重HPV感染的模式:系统性审查和元分析
Dan Zhou1,2, Jing Xue3, Yaqiong Sun4
1Maternal and Child Health Development Research Center, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Heliyon
|September 12, 2024
概括
这项研究揭示了人类乳头瘤病毒 (HPV) 感染的全球模式,确定了常见的HPV类型和区域变异. 这些发现强调了针对HPV疫苗接种策略和宫癌查的必要性.
科学领域:
- 流行病学和公共卫生.
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 关于人类乳头瘤病毒 (HPV) 感染模式的数据有限,特别是在区域差异方面.
- 之前关于HPV感染流行率和基因型的研究往往是小规模的.
研究的目的:
- 系统地检查单个和多个HPV感染的全球模式.
- 确定最常见的HPV基因型及其区域分布.
- 分析不同年龄组和宫病变严重程度的HPV感染患病率.
主要方法:
- 在PubMed,Embase和Web of Science数据库中进行了全面的文献搜索.
- 随机效应元分析被用于计算汇总的HPV感染流行率.
- 用小组分析和出版偏见测试 (Egger,Begg) 来探索异质性.
主要成果:
- 这项研究包括了121项研究,共有160多万参与者.
- 在全球范围内,HPV16是单一 (7.05%) 和多重 (4.91%) 感染中最常见的基因型. 观察到区域差异,在亚洲流行HPV52/58,在欧洲/美洲流行HPV31/51.
- 随着宫病变的严重程度,HPV感染的患病率增加,在单次感染的宫癌病例中达到62.88%.
结论:
- 了解HPV感染模式对于开发有针对性的HPV疫苗至关重要.
- 公共卫生倡议应侧重于教育年轻女性关于HPV疫苗接种,并鼓励老年女性定期进行宫癌查.
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