相关实验视频
Updated: May 10, 2026

13:22
Measurement of γHV68 Infection in Mice
Published on: November 22, 2011
13.6K
错误地将急性帕尔沃病毒B19感染分类为系统性风湿性疾病的高风险
Bernardo D'Onofrio1, Giulia Virelli1, Elisa Pedrollo1
1Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Rheumatology advances in practice
|September 12, 2024
概括
急性帕尔沃病毒B19感染可以模仿自身免疫性疾病. 几乎所有呈阳性抗核抗体 (ANA) 的患者都符合全身性红斑狼 (SLE) 标准,突出显示了风湿病患者误诊的风险.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 帕尔沃病毒B19通常会导致儿童的感染性红血热,并会导致成人出现类风湿症状.
- 这些病毒表现可能类似于自身免疫性疾病,使诊断复杂化.
- 准确的诊断至关重要,因为帕尔沃病毒B19感染可以模仿系统性红斑狼 (SLE) 和类风湿性关节炎 (RA).
研究的目的:
- 确定急性帕尔沃病毒B19感染患者中符合风湿性疾病分类标准的比例,特别是RA和SLE.
- 评估帕尔沃病毒B19感染症状与已建立的风湿病诊断标准之间的重叠.
主要方法:
- 评估了54名急性帕尔沃病毒B19感染患者的队列,这些患者呈现了类风湿病情.
- 收集了临床数据,包括症状和身体发现.
- 评估了血清标记物,如抗核抗体 (ANA),抗dsDNA,抗脂和类风湿因子.
主要成果:
- 大多数患者是女性 (78%),平均年龄为45岁.
- 常见的症状包括关节痛 (94%),关节炎 (50%),发烧 (44%) 和皮疹 (35%).
- 值得注意的是,93%的ANA阳性患者符合SLE分类标准,38%的关节炎患者符合RA标准.
结论:
- 急性帕尔沃病毒B19感染呈现出多种表现,可以很好地模仿自身免疫性风湿性疾病.
- 很大一部分患有帕沃病毒B19感染的患者,特别是那些阳性ANA患者,符合SLE的分类标准.
- 临床医生必须考虑像parvovirus B19这样的病毒感染,以避免错误地分类患有风湿病的患者.
相关概念视频
Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
Acute Pharyngitis
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

