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鼻腔内施用乙胺与乙胺 - 德克斯梅德托米丁组合用于小儿科患者的前期治疗,这些患者接受了斜视手术:一项随机对照试验
Hui Qiao1, Yan Zhuang1, Peipei Lv1
1Department of Anesthesiology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Translational pediatrics
|September 12, 2024
概括
单独注入鼻腔以斯基坦胺可以为儿科斜视手术患者提供更快的镇静作用. 然而,胺和德克斯梅德托米丁的组合导致胃肠道副作用较少.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术前的焦虑和恐惧在接受手术的儿童中很常见.
- 埃斯凯特胺和德克斯梅德托米丁的组合在镇静和止痛方面得到了探索.
- 这项研究评估了鼻腔内注射的埃斯基坦胺与儿科眼手术中的组合.
研究的目的:
- 为了比较单独注射鼻腔以斯基他明的疗效与与德克斯梅德托米丁联合治疗儿童手术前镇静的疗效.
- 评估镇静水平,开始时间和不良影响.
- 评估对静脉注射管道成功和患者/家长焦虑的影响.
主要方法:
- 180名接受眼手术的学龄前儿童 (2-6岁) 被随机分为三组.
- 两组接受了鼻内胺 (2毫克/公斤),或不同剂量的胺胺.
- 结果包括修改的耶鲁手术前焦虑量表 (mYPAS),镇静量表 (SS) 和不良事件.
主要成果:
- 与组合组 (18.1-18.4 分钟) 相比,鼻内胺 (K 组) 的镇静开始更快 (11.4 分钟).
- 焦虑和镇静得分在所有组都得到改善,K组最初的焦虑程度较低.
- 胃肠道事件在仅服用乙胺的组 (K组) 中显著增加.
结论:
- 鼻腔内以斯基坦胺 (2毫克/公斤) 提供了一个更快的镇静发作为儿科斜视手术.
- 艾斯基坦胺和德克斯梅德托米丁的组合可能会减少胃肠道不良反应.
- 这两种方案都有效地减少了手术前的焦虑,并促进了手术.
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