对具有抗喘作用的植物和草药化合物的最新综合审查
Mohammad Amin Rajizadeh1, Hamid Najafipour2, Mohammad Abbas Bejeshk3
1Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Evidence-based complementary and alternative medicine : eCAM
|September 12, 2024
概括
本综述汇编了关于治疗喘的植物及其化合物的研究. 研究结果显示,58种植物和32种化合物具有抗喘活性,为新药开发提供了潜力.
科学领域:
- 药理学和草药医学 药理学和草药医学
- 呼吸系统医学 呼吸系统医学
- 自然产品化学 自然产品化学
背景情况:
- 全球范围内喘患病率正在增加,传统治疗方法的局限性导致人们对替代疗法产生兴趣.
- 草药越来越多地被用于抗过敏和抗喘性质,正在研究植物衍生化合物.
- 了解这些天然化合物的作用机制可能会导致开发新的喘药物.
研究的目的:
- 系统地审查和汇编关于具有实验验证实抗喘作用的植物和活性剂的发现.
- 巩固关于草药及其化合物的知识,以应用于潜在的喘治疗应用.
- 为了确定在控制喘症状方面已证实有效的植物和化合物.
主要方法:
- 在主要的科学数据库 (Scopus,PubMed,Web of Science等) 进行了全面的文献搜索. ) 的情况.
- 搜索涵盖了从1986年到2023年11月的时期,重点是研究研究喘的草药和化合物的研究.
- 数据提取的重点是实验证实抗喘活动和相关性质.
主要成果:
- 该审查确定了58种表现出抗喘活性的植物.
- 32种不同的草药提取化合物显示出抗喘性质.
- 另外32种植物表现出抗炎,抗氧化或支气管扩展作用,需要进一步研究喘治疗.
结论:
- 临床和临床前证据支持草药在改善喘症状方面的有效性.
- 来自植物的生物活性化合物是开发新的有效抗喘药物的有希望的来源.
- 许多天然化合物对于治疗喘具有显著的治疗潜力.
更多相关视频
相关概念视频
01:20Antiasthma Drugs: Muscarinic Receptor Antagonists
259
Muscarinic receptor antagonists, also known as antimuscarinic agents, are a class of bronchodilators used to treat asthma, although they are more commonly used to treat COPD. They work by inhibiting the action of acetylcholine (ACh), a neurotransmitter, on muscarinic receptors found in the airways.
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
Antimuscarinic agents compete with ACh for the same binding site on the muscarinic receptors. By binding to these receptors, they inhibit the downstream effects of ACh and block the parasympathetic...
259
01:24Antiasthma Drugs: Methylxanthines
209
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
209
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
228
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
228
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
239
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
239
01:19Antiasthma Drugs: Leukotriene Modifiers
253
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
253
01:17Drugs Used in Lower Respiratory Disorders: Overview
362
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
362