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尿液中自由的葡萄糖氨基甘识别了患有早期高度膀癌的高风险成年人

Francesco Gatto^1,2,3, Sinisa Bratulic^2,3, Francesca Maccari⁴

¹Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

European urology open science

|September 12, 2024

概括

尿液中自由的葡萄糖氨基甘 (GAGome) 样本显示出对非侵入性膀癌 (BCa) 查的前景. 这种生物标志物可以在7年内识别患BCa高风险的个体,有助于早期检测和降低死亡率.

科学领域:

生物化学生化学
在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

膀癌 (BCa) 查可以通过早期发现高度疾病来降低死亡率.
目前的非侵入性生物标志物缺乏有效查所需的特异性.
尿液中自由的葡萄糖氨基酸 (GAGome) 概况为BCa代谢的潜在生物标志物.

研究的目的:

评估尿路GAGome作为早期膀癌检测的非侵入性生物标志物的潜力.
使用GAGome功能开发和验证BCa风险的预测得分.
评估GAGome评分能够识别患BCa.高风险的个体的能力.

主要方法:

预期病例控制研究,以开发基于GAGome的BCa的预测得分.
基于人口的队列 (生命线队列研究) 的回顾性分析以验证得分.
综合年龄,性别和GAGome分数的后勤回归模型被用来预测7年后的BCa风险.

主要成果:

在患有BCa.的人群中观察到三种GAGome特征的变化.
开发的GAGome分数歧视了BCa,其AUC为0.77.
在假定健康的队列中,GAGome得分独立预测了7年后的BCa (p < 0.001),改善了单独对年龄和性别的风险预测.

结论:

尿路自由GAGome在BCa中发生了变化,并作为一种特定的,非侵入性的生物标志物.
该GAGome得分可以识别患BCa高风险的成年人,不论年龄和性别.
这种生物标志物有潜力设计风险分层的,有针对性的膀癌查计划.

关键词:

膀癌是一种癌症.癌症的代谢癌症的代谢葡萄糖氨基氨基甘油查检查查检查查检查尿路生物标志物尿路生物标志物

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