稳定精神分裂症患者的异常享乐过程:与负面症状和社会功能之间的关系
Qi Zhou1, Yue Zheng2, Xiaodong Guo2
1The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Schizophrenia research. Cognition
|September 12, 2024
概括
患有稳定精神分裂症的患者表现出对奖励的动机降低,他们更喜欢身体而不是认知上的努力. 无情和负面症状显著影响他们的社会功能和整体表现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 在奖励处理中的核心缺陷 - - 安赫多尼亚 - - 在相当一部分稳定的精神分裂症患者中仍然存在.
- 有限的研究已经探索了稳定的精神分裂症的多方面的奖励处理性能,尽管有证据表明,在身体和认知努力的基础上存在不同的神经机制.
研究的目的:
- 研究稳定精神分裂症患者的奖励处理的不同方面,包括动机和基于努力的决策.
- 在这个人群中检查无情,负面症状,神经认知功能,社会功能和奖励处理性能之间的关系.
主要方法:
- 在61名稳定精神分裂症患者 (SSZ) 和46名健康对照人群 (HCs) 中,他们使用了奖励任务 (EEfRT) 和自我报告问卷的基于努力的支出.
- 通过艰难任务选择的百分比 (HTC%) 评估动机,并评估SSZ患者的负面症状,神经认知和社会功能.
主要成果:
- 与HC相比,SSZ患者报告了较高水平的消费性,预期性和社会无情感.
- 在奖励任务中,SSZ患者的HTC%显著降低,特别是在认知力度任务中,这表明动机降低.
- 认知任务表现与负面症状的动机和快乐维度相关,而身体任务表现与表达维度相关. 预期性无情感和与社会功能得分 (PSP) 相相关的负面症状.
结论:
- 稳定的精神分裂症患者经历了社会,消费和预期的无情感,加上奖励动机的减少.
- 这些患者在寻求奖励时更喜欢体力而不是认知上的努力,这表明不同类型的努力背后存在着不同的神经心理过程.
- 预期性无聊与精神分裂症患者的社会功能受损密切相关.
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