视网膜微结构变化反映了治疗相关的认知功能障碍在患有较低级别质瘤的患者
Arina Nisanova1, Ashutosh Parajuli2, Bhavna Antony2
1Department of Ophthalmology & Vision Science, University of California Davis, Sacramento, California.
Ophthalmology science
|September 12, 2024
概括
视网膜变化和瘤特征与质瘤患者的认知功能障碍相关. 这些发现表明,视网膜生物标志物可以帮助诊断和监测与治疗相关的认知功能障碍 (TACD).
科学领域:
- 眼科和神经病学 眼科和神经病学
- 神经瘤学和癌症研究
背景情况:
- 较低级别的质瘤可能导致与治疗相关的认知功能障碍 (TACD).
- 确定TACD可靠的生物标志物对于患者管理至关重要.
研究的目的:
- 为了研究微观结构性视网膜变化,瘤特征和低度质瘤患者TACD的阿波利波蛋白E (APOE) ε4多态性之间的相关性.
- 评估视网膜生物标志物在检测和监测认知功能障碍方面的潜力.
主要方法:
- 一项包括16名低度质瘤患者和对照组在内的队列研究.
- 使用蒙特利尔认知评估 (MoCA) 评分和6个月间隔的视网膜变化评估认知状态.
- 评估APOE基因型定型,瘤细节和TACD与TACD的相关性,使用部分最小平方差异 (PLSD) 模型.
主要成果:
- 56%的患者表现出异常的认知能力 (MoCA <26/30).
- 较差的MoCA得分与叶瘤和小腺质瘤有关.
- 患有TACD的患者表现出显著的辐射周毛细血管密度损失;PLSD模型使用视网膜和瘤特征以77%的准确度确定了TACD.
结论:
- 视网膜微结构性变化可以作为TACD的生物标志物,在较低级别质瘤患者.
- 叶瘤和小腺瘤可能会增加对TACD的敏感性.
- 视网膜标记物可以改善TACD的诊断和监测,因此需要进一步研究APOE ε4的作用.
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