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Noninvasive, High-throughput Determination of Sleep Duration in Rodents
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恢复:每晚一次的oxybate剂量偏好和每晚两次的oxybate的夜间经验
Asim Roy1, Thomas Stern2, John Harsh3
1Ohio Sleep Medicine Institute, Dublin, OH, USA.
麻醉症患者绝大多数人更喜欢每晚一次的延长释放氧酸盐 (ON-SXB),而不是每晚两次的即时释放 (IR) 氧酸盐. ON-SXB简化了剂量,减少了治疗负担,并改善了对麻醉症管理的遵守.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 麻醉症的治疗通常涉及氧酸盐,通常每天服用多次剂量.
- 立即释放 (IR) 氧酸盐需要半夜 (MON) 剂量,这对坚持和患者体验构成挑战.
- 延长释放配方旨在提高治疗方便性和患者的治疗结果.
研究的目的:
- 评估患者对每晚一次的延长释放氧酸盐 (ON-SXB) 与每晚两次的即时释放 (IR) 氧酸盐相比的偏好.
- 为了评估与IRoxybate的午夜 (MON) 剂量相关的治疗负担和坚持.
- 为了确定患者对简化ON-SXB剂量方案的满意度.
主要方法:
- 一项开放标签,切换研究 (RESTORE) 招募了患有麻醉症的参与者,从IRoxybate切换到ON-SXB.
- 参与者填写了调查问卷,评估MON IR氧酸盐的不良事件,配方之间的偏好和坚持.
- 开始使用ON-SXB的剂量是基于之前的IR氧酸盐疗法.
主要成果:
- 在130名转换参与者中,93.9%的人更喜欢ON-SXB而不是每晚两次的IRoxybate.
- 在基线时,69.2%的患者错过了第二剂IR氧酸盐,导致80%的患者第二天症状恶化.
- 显著的负担包括与MON IR氧酸盐剂量相关的昏昏欲睡 (51%的服用第二剂量较晚的人),跌倒 (8%) 和受伤 (4%).
结论:
- 立即释放 (IR) 氧酸盐的午夜 (MON) 剂量带来了相当大的治疗负担和坚持问题.
- 患者强烈喜欢延长释放氧酸盐 (ON-SXB) 的简化,每晚一次的剂量计划.
- ON-SXB为麻醉症管理提供了一个更方便和潜在的更安全的替代方案.
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