在儿童结核性脑膜炎中发生症性交感性过活:一个新的协会
Prashant Jauhari1, Sonali Singh1, Agam Jain1
1Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
松性交感性过活性 (PSH) 是儿童结核性脑膜炎的晚期并发症,影响14.6%的病例. 在这些儿童中,预计PSH有不明原因的发烧或神经衰退.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 结核性脑膜炎 (TBM) 在儿童中可能导致严重的神经后果.
- 发性交感性多动性 (PSH) 是各种神经疾病中公认的并发症.
- 儿童TBM中PSH的患病率和特征尚未得到充分确立.
研究的目的:
- 估计诊断为TBM的儿童中PSH的患病率.
- 描述PSH在这个人群中出现的临床特征和时间.
- 确定与TBM中PSH相关的潜在风险因素和结果.
主要方法:
- 从2019年9月到2022年1月,对6个月至14岁的儿童患有TBM的医院记录进行了回顾性分析.
- 自2019年9月以来,使用心交感高活性评估措施 (PSH-AM) 对PSH进行系统查.
- 使用儿科大脑性能类别评分对3个月结果的前性评估.
主要成果:
- 在41名TBM儿童中有6名 (14.6%) 发现了PSH.
- PSH发作发生在TBM诊断后4至25周之间.
- 与没有PSH的儿童相比,患PSH的儿童年龄更小 (中位数为5岁),水头发病发病率更高 (83.3%).
- 患有PSH的儿童的住院时间显著延长 (平均71.2天与20.8天).
结论:
- PSH是儿童结核性脑膜炎的显著晚期并发症,发生在14.6%的病例中.
- 早期识别PSH至关重要,特别是在儿童出现复发性发烧或神经系统恶化的情况下.
- 在TBM患者中,PSH与年轻的年龄,脑水和长时间住院有关.
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