黄摄入量与亚临床动脉样硬化之间的关联:动脉样硬化多民族研究
Nicola P Bondonno1,2, Benjamin H Parmenter1,3, Kevin Murray4
1Nutrition & Health Innovation Research Institute, Royal Perth Hospital Research Foundation, Edith Cowan University, Australia (N.P.B., B.H.P., C.P.B., L.C.B., J.R.L., J.M.H.).
Arteriosclerosis, thrombosis, and vascular biology
|September 12, 2024
概括
饮食中较高的黄类药物摄入量与外周和动脉动脉样硬化的几率降低有关. 摄入富含黄胺的食物可能会对这些疾病提供保护.
科学领域:
- 心血管疾病流行病学
- 营养科学 营养科学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 黄素正在研究其在减轻动脉样硬化心血管疾病方面的潜在作用.
- 有证据表明,黄类药物的作用在不同的血管床上可能有所不同.
- 有限的研究探讨了不同风险人群中与亚临床动脉样硬化标志物的黄类化合物相关性.
研究的目的:
- 为了检查饮食中的黄酸盐摄入量与亚临床动脉样硬化指标之间的关联.
- 通过人口统计和生活方式因素来调查潜在的效果修改.
主要方法:
- 来自多民族动脉样硬化研究 (MESA) 的5599名参与者的分析.
- 通过食物频率调查问卷估计的食黄类素摄入量.
- 在两个时间点评估的亚临床动脉样硬化,使用脚-手腕指数,动脉斑块,内心介质厚度和冠状动脉化.
- 采用了重复测量模型和分层分析.
主要成果:
- 较高的总黄类药物摄入量与较低的外周动脉疾病 (关节-手腕指数<1) 和大脑动脉斑块的几率有关.
- 某些特定的黄类化合物,如黄醇,黄醇单体和氨酸,与低脚-手腕指数和动脉斑块的几率降低有关.
- 没有发现与内心介质厚度或冠状动脉化有显著的关联.
- 关联因性别,种族/种族或吸烟状况而没有显著差异.
结论:
- 饮食中较高的黄类药物摄入量与多民族人口中外周和动脉动脉样硬化的几率降低有关.
- 增加富含黄类食物的消费可能会在这些血管床上保护动脉样硬化.
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