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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Antibody Actions01:26

Antibody Actions

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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相关实验视频

Updated: Jun 13, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

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补充向治疗:我们还在那里,还是刚刚开始?

Daniel Ricklin1

  • 1Molecular Pharmacy Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

European journal of immunology
|September 12, 2024
PubMed
概括
此摘要是机器生成的。

补充系统疗法已经取得了显著的进步,为许多疾病提供了可行的治疗方法. 本次审查强调了补充向药物开发的关键里程碑和未来方向.

关键词:
补充系统的补充系统.药物发现和开发 药物发现和开发治疗方法 治疗方法

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Depletion of Specific Cell Populations by Complement Depletion
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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相关实验视频

Last Updated: Jun 13, 2025

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Depletion of Specific Cell Populations by Complement Depletion
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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科学领域:

  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.
  • 药物发现 药物发现 药物发现

背景情况:

  • 补体系统是一个关键的免疫媒介,与各种疾病有关.
  • 从历史上看,将补充系统用于治疗目的是具有挑战性的.
  • 最近的进展表明了补充向疗法的临床和商业可行性.

研究的目的:

  • 审查补充药物发现和开发的历史里程碑.
  • 调查目前批准的补充特异性疗法及其适用情况.
  • 提供对该领域未来进步的见解.

主要方法:

  • 关于补充药物的发现和开发的文献综述.
  • 对已批准的补充特异性疗法和临床适应症的分析.
  • 探索补充疗法的新兴趋势和未来前景.

主要成果:

  • 在过去的二十年中,补充向疗法的领域迅速扩大.
  • 现在有十几种不同的补充特异性疗法可供使用,用于治疗八种疾病.
  • 众多临床试验和非标签用途进一步证明了这些疗法的日益增长的影响.

结论:

  • 补充向疗法已经从具有挑战性的概念演变为主流的临床选择.
  • 该领域继续进步,正在进行的研究和开发有望进一步突破.
  • 预计未来的进展将扩大治疗模式,并解决更广泛的疾病.