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Updated: Jun 13, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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在选中,分子动力学模拟和结合自由能量识别了破坏p53稳定的单点突变,并减少了与DNA的结合

Shahidul M Islam1, Md Mehedi Hasan1, Jahidul Alam2

  • 1Department of Chemistry, Delaware State University, Dover, Delaware, USA.

Proteins
|September 12, 2024
PubMed
概括

识别有害的p53突变是预防癌症的关键. 计算工具标记了C141Y,C238S和L265P p53变体,显示DNA结合减少和不稳定性增加,构成潜在的人类健康风险.

关键词:
在MM/GBSA中使用.罗塞塔Flex ddg ddg 的时间结合性亲和力是一种结合性亲和力.分子动态模拟分子动态模拟非同义词的单核酸多态性.在 p53 里,p53 是一个 p53 的类型.

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