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嗅觉训练结果的年龄相关差异:一个前性队列研究
Amelia S Lawrence1, Jodi Veach2, Rahul Alapati1
1Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.
International forum of allergy & rhinology
|September 12, 2024
概括
嗅觉训练 (OT) 对年轻人和老年人具有后COVID嗅觉功能障碍 (OD) 是有效的. 虽然两组在3个月后都有显著的改善,但年轻人在生活质量方面经历了更早的主观改善.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
背景情况:
- 嗅觉功能自然会随着年龄的增长而下降.
- 在患有嗅觉功能障碍 (OD) 的老年人中,嗅觉训练 (OT) 的有效性仍未得到充分研究.
- 这项研究调查了OT有效性的年龄相关差异,特别是在COVID-19后OD患者中.
研究的目的:
- 为了比较嗅觉训练 (OT) 在年轻人 (≤50岁) 与老年人 (51岁以上) 嗅觉功能障碍 (OD) 的有效性.
- 评估经过6个月的OT计划后,嗅觉功能的恢复和生活质量的改善.
- 为了确定嗅觉恢复和主观症状改善的时间表中的潜在与年龄相关的差异.
主要方法:
- 预计将56名COVID-19后OD参与者纳入OT注册表.
- 标准化的家庭OT计划,每天完成两次,持续6个月.
- 嗅觉测试 (AROMA) 和生活质量调查 (SNOT-22, QoD-NS) 在基线,3个月和6个月.
主要成果:
- 年轻和年长的队列在3个月的OT后都显示出显著的嗅觉功能的改善 (AROMA分数).
- 在AROMA,QoD-NS或SNOT-22得分中的队列之间没有观察到任何时间点的显著差异.
- 年轻的参与者报告生活质量指标 (QoD-NS,SNOT-22) 早在3个月后有所改善,而年长的参与者在3到6个月之间有所改善.
结论:
- 嗅觉训练 (OT) 是一种有效的干预措施,用于改善后COVID-19嗅觉功能障碍 (OD) 的年轻人和老年人的嗅觉功能.
- 虽然客观的嗅觉改善在3个月后发生了类似的情况,但对恢复和生活质量改善的主观经验在年轻人中表现得更早.
- 年龄并不妨碍整体的OT疗效,但可能会影响主观症状解决的时间.
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