管理胆酸腹:争议的方面
Julian R F Walters1,2, Rafid Sikafi1,2
1Department of Gastroenterology, Imperial College Healthcare NHS Trust.
Expert review of gastroenterology & hepatology
|September 12, 2024
概括
胆酸腹是一种常见但经常被误诊的疾病,需要进一步研究其原因,诊断和治疗方法. 目前的管理重点是使用胆酸分离剂和新兴的治疗方法,如利拉格卢提德来控制症状.
科学领域:
- 胃肠病学 胃肠病学
- 消化系统健康 消化系统健康
- 临床医学 临床医学
背景情况:
- 胆汁酸性腹 (BAD) 是肠道症状的常见原因,经常被忽视或误诊.
- 讨论了BAD的管理策略,强调需要更明确的诊断和治疗指南.
研究的目的:
- 审查目前的理解,并确定胆酸腹未来研究的领域.
- 强调需要进一步投资于BAD的原因,诊断和治疗.
主要方法:
- 对有关胆酸腹的现有文献的综述.
- 分析诊断方法和治疗选择,包括药理和饮食干预措施.
主要成果:
- 胆酸分离剂 (例如,colesevelam) 是主要的治疗方法,目前正在研究最佳使用方法.
- 新兴疗法,如GLP-1受体激动剂 (例如,利拉格卢提德) 显示有效性,但机制和更广泛的适用性需要研究.
- FXR激动剂显示出潜力,但需要进一步验证;饮食的作用需要更正式的研究.
结论:
- 进一步的研究和投资对于改善胆酸性腹的诊断和管理至关重要.
- 全球需要诊断测试的标准化和治疗策略的完善.
相关概念视频
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
187
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
187
Drugs for Treatment of Diarrhea-Predominant IBS
153
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
153
Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
111
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
111
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
324
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
324
Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
178
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
178


