相关实验视频

Updated: Jun 13, 2025

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

RAC1作为预后因素,与肝肝细胞癌的免疫透相关

Yuan Li¹, Aidong Gu², Lili Yang¹

¹Department of Chemotherapy, The Second Hospital of Nanjing，Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

Journal of cancer research and clinical oncology

|September 12, 2024

概括

升高的RAC1表达促进肝细胞癌 (LIHC) 的生长和迁移,对患者的生存产生负面影响. 通过影响瘤免疫微环境,RAC1可以作为预后生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

由于检测迟到,肝细胞癌 (LIHC) 存在诊断和治疗方面的挑战.
对LIHC缺乏有效的预后生物标志物.
在LIHC中RAC1及其瘤微环境的作用尚不清楚.

研究的目的:

研究RAC1表达和LIHC预后之间的关联.
探索RAC1对LIHC免疫透微环境的影响.
评估RAC1作为LIHC的潜在预后生物标志物.

主要方法:

对RAC1表达和临床相关性进行癌症基因组图谱 (TCGA) 数据的分析.
卡普兰-梅尔和考克斯回归用于整体生存分析.
在体外和体内研究使用RAC1倒置LIHC细胞来评估增殖和迁移.

主要成果:

在LIHC组织中,RAC1的表达显著更高,并且与晚期相关.
高RAC1表达是整体存活期的独立负预后因素.
降低RAC1抑制LIHC细胞的增殖和迁移;RAC1与Th2和巨细胞透相关.

结论:

RAC1促进LIHC的进展,并影响免疫细胞的透.
RAC1是LIHC的潜在预后生物标志物,与癌症进展和免疫微环境变化相关.

关键词:

免疫系统的透.肝脏肝细胞癌是肝脏肝细胞癌.总体生存率总体生存率在 RAC1 中,RAC1 包含了 RAC1.

更多相关视频

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...