目前关于氧化在牙周病和血压中的作用的临床框架
Leonel Lima1, Sara Gaspar2, Bárbara S Rocha3
1Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Monte da Caparica, Almada, Portugal.
Clinical oral investigations
|September 12, 2024
概括
氧化 (NO) 和其衍生物,酸盐和酸盐,与牙周和心血管疾病有关. 饮食中酸盐可能会改善NO的生物可用性,而某些口水可以破坏这种途径,可能会影响血压.
科学领域:
- 生理学 生理学 生理学
- 微生物学 微生物学
- 心血管健康 心血管健康
背景情况:
- 氧化 (NO) 是一个关键的信号分子,参与血管平衡,炎症和免疫反应.
- 及其衍生物,亚酸盐和酸盐,都与牙周和心血管疾病有关.
- 了解这些分子与疾病致病的相互作用,对于开发有效的干预措施至关重要.
研究的目的:
- 探索氧化 (NO),酸盐和酸盐与牙周和心血管疾病之间的关联.
- 阐明这些氧化在牙周炎-高血压联系中的作用.
- 识别知识缺口和该领域实验方法的关键方面.
主要方法:
- 进行了全面的文献审查.
- 分析了人类唾液和血中酸盐和酸盐度的数据.
- 评估了这些化合物对牙周和心血管健康的影响.
主要成果:
- 富含酸盐的饮食通过有利地改变口腔微生物群,增加酸盐和酸盐水平来改善口腔健康.
- 赫西丁 (CHX) 口水会破坏酸盐-酸盐-NO通路,降低NO的生物可用性,并可能增加血压.
- 在牙周病患者中观察到酸盐度的增加,尽管研究存在局限性.
- NO的生物可用性可能会受到活性氧物种 (ROS) 和内皮氧化合成酶 (eNOS) 分离的影响.
结论:
- 研究表明,NO水平与心血管和牙周疾病的发展之间存在联系.
- 连接NO,牙周病和高血压的确切机制需要进一步阐明.
- 饮食中酸盐补充剂和微生物组调节显示有望增加NO的生物可用性.
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