异形偏距感官多神经病变和纤维肌痛综合征:一个比较的表型研究研究
Jamie Burgess1,2, Anne Marshall3, Leandros Rapteas3
1Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. J.G.Burgess@liverpool.ac.uk.
Pain and therapy
|September 12, 2024
概括
小纤维病理 (SFP) 存在于痛苦的异常偏远感官多神经病变 (IDSP) 和纤维肌痛综合征 (FMS),表明共享的神经损伤机制. 感官变化与IDSP中的SFP有关,但与FMS无关.
科学领域:
- 神经学 神经学
- 疼痛医学 医学 疼痛医学
- 眼科医生 眼科 眼科
背景情况:
- 疼痛性异常偏远感官多神经病变 (IDSP) 和纤维肌痛综合征 (FMS) 是不清楚起源的慢性疼痛状况.
- 讨论了小纤维病理 (SFP) 在FMS中的作用.
- 本研究研究了IDSP和FMS中的SFP及其与感官症状的关系.
研究的目的:
- 在IDSP和FMS患者中量化小神经纤维病理.
- 在这些条件下探索SFP和感官表型之间的关系.
- 根据小纤维病理和感官功能来区分IDSP和FMS.
主要方法:
- 评估了73名个人 (25名FMS,23名IDSP,25名健康对照) 的队列.
- 方法包括神经学检查,问卷,感官测试和角膜共聚焦显微镜.
- 使用角膜神经纤维长度确定了小纤维病理.
主要成果:
- 与FMS和对照组相比,IDSP患者的热和机械感官功能受损,神经病症得分升高.
- 与IDSP和对照组相比,FMS患者表现出增强的热和压力疼痛反应和改变的风起比率.
- 在66.6%的参与者中检测到小纤维病理 (13/25 FMS,22/23 IDSP),FMS中角膜神经密度降低,IDSP中角膜神经测量总体降低.
结论:
- 在FMS和IDSP中存在小纤维病理,这表明小神经纤维疾病的共同潜在机制.
- 超过一半的参与者在两种情况都显示了感官损失和收益的混合,表明重叠的病理生理过程.
- 在IDSP中,感官表型与SFP相关,但在FMS中没有观察到这种关联.
关键词:
角膜共聚焦显微镜的使用.纤维肌痛综合征 纤维肌痛综合征异常远端感官多神经病变 (Idiopathic distal sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic distal sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy) 是一种异常远端感官多神经病变 (Idiopathic sensory polyneuropathy).神经病变性疼痛 神经病变性疼痛疼痛的特征 疼痛的特征定量感官测试 定量感官测试 定量感官测试感官表型的形成是感官表型的形成.小纤维的小纤维是什么?
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