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定义家族长寿,并制定一个家族长寿得分,用于在出生队列中进行公正的表观遗传研究

Jasmin C Pflaum¹, Vincent D Gaertner¹, Susanne Brandstetter^2,3

¹Department of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), of the University of Regensburg & the Order of St. John at the St. Hedwig Hospital, Regensburg, Germany.

|September 12, 2024

概括

可以使用新生儿的数据计算适应的家庭长寿得分 (FLoSS). 这使得长寿和影响寿命的表观遗传因素的早期,公正的预测.

科学领域:

遗传学和表观遗传学
人口健康人口健康
老年学是指老年学的学科.

背景情况:

家庭史通过遗传和表观遗传因素影响长寿.
前性研究需要早期,公正的长寿预测因素.
最初的家庭长寿选择得分 (FLoSS) 仅限于老年人群.

研究的目的:

调整家庭长寿选择得分 (FLoSS) 用于出生队列.
评估在产后收集FLoSS相关数据的可行性.
为了使长寿的表观遗传预测因素的前性研究.

主要方法:

使用了德国出生队列KUNO-Kids.
评估了适应FLoSS的数据收集时间.
为551个参与家庭计算了适应的FLoSS.

主要成果:

调整后的FLoSS为551个家庭计算,平均得分为-0.15.
在3.3%的家庭中发现了异常长寿 (适应FLoSS≥7).
异常长寿标志物的患病率与老年人队列中的原始FLoSS相似.

结论:

通过使用产后数据,可以实现适应的FLoSS.
这种适应的得分可以作为研究长寿早期表观遗传预测因子的工具.
允许对寿命的遗传和表观遗传基础进行公正的前性研究.

关键词:

在 FLoSS 中使用 FLoSS.在KUNO-Kids的研究中,KUNO-Kids学习.出生的队列队列出生.家庭长寿家庭长寿长寿长寿是一个问题.新生儿新生儿的新生儿

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