餐后代谢分析显示,在腹后低血糖症中,血代谢失调
Rafael Ferraz-Bannitz1,2, Berkcan Ozturk1,2, Cameron Cummings1
1Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
The Journal of clinical investigation
|September 12, 2024
概括
腹后低血糖症 (PBH) 可能是由于饭后血清的增加引起的. 这项研究发现PBH患者的禁食和食后血清激素水平较高,表明血清激素是治疗这种疾病的治疗标.
科学领域:
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 腹腔外科手术有效治疗肥胖和2型糖尿病,但可能导致腹腔后低血糖症 (PBH).
- PBH的特点是饭后几个小时血糖降低,这与高的隐素和胰岛素水平有关.
- 对于PBH的精确代谢媒介的理解尚不完全.
研究的目的:
- 为了确定关键的代谢变化和潜在的调解者,有助于PBH的病理生理学.
- 研究特定代谢物的作用,包括托衍生物和脂质在PBH发展中的作用.
- 探索血清素作为潜在的致病因子和PBH的治疗点.
主要方法:
- 血代谢组分析对PBH患者,无症状Roux-en-Y胃旁路术后 (RYGB后) 患者和非手术对照进行.
- 在禁食状态和混合饮食后30分钟和120分钟收集样本.
- 在小鼠身上进行了体内研究,以评估血清素的使用和对抗作用对葡萄糖和胰岛素水平的影响.
主要成果:
- 与无症状对照组相比,PBH患者表现出三酸循环中间体和β-基酸盐的禁食水平升高,以及减少的氨基酸和多不和脂类.
- 在PBH患者中,禁食血血清和相关代谢物显著降低.
- 餐后血清水平在PBH患者中异常升高,并且血清给药在小鼠中诱导了低血糖症,这种情况在使用血清受体对抗剂时是可逆的.
结论:
- 餐后血清激素水平升高似乎是PBH发展的重要因素.
- 涉及氨基酸,脂质和能量基质的代谢失调与PBH有关.
- 中毒素代表了一个有前途的治疗目标,用于管理后腹性低血糖症.
相关概念视频
01:19Overview of Carbohydrate Metabolism
805
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
805
01:15Hypoglycemia and Glucagon
216
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
216
01:18Metabolic States of the Body: The Postabsorptive State
277
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
277
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.5K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.5K
01:25Metabolic States of the Body: The Absorptive State
670
During the absorptive state, which lasts approximately four hours after a meal, the body absorbs nutrients from the gastrointestinal tract. The carbohydrates, proteins, and lipids we consume are broken down into monosaccharides, amino acids, and free fatty acids for absorption. While carbohydrates and proteins are absorbed as-is, lipids are absorbed in their broken-down forms and then re-esterified into triglycerides within enterocytes before being packaged into chylomicrons. These absorbed...
670
01:36Carbohydrate Metabolism
10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K